By CapitalSnitch Research Desk · updated Oct 11, 2026 · data from SEC filings and official Congress disclosures
Spyre Therapeutics, Inc. executives and directors have only been selling lately: seven insiders sold about $443 million of stock over 12 months, with no open-market purchases.
Keep in mind most insider selling is routine — stock-based pay has to be converted to cash at some point.
Big money check: 265 institutions held SYRE as of Q2 2026, and more funds bought than sold. Looking at the quarterly pattern: 5 quarters in a row of net selling by insiders. Insiders bought in 0 of the last 7 full quarters.
Are insiders buying or selling SYRE stock?
In the last 12 months Spyre Therapeutics, Inc. insiders made open-market purchases worth about $0 and sales worth about $443 million. Data comes from SEC Form 4 filings, updated every 30 minutes on CapitalSnitch.
When was the last insider trade in SYRE?
The most recent open-market insider trade in SYRE was filed on 2026-10-02.
How many institutions own SYRE?
265 investment managers reported holding SYRE in SEC Form 13F filings for Q2 2026.
Has any member of Congress traded SYRE?
No congressional trades in SYRE were reported in the past two years. The full list is free on CapitalSnitch.
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Public-record data for research and education, not investment advice. Insider sales are often pre-planned (10b5-1).
Congress data: Data derived from public disclosures filed under the Ethics in Government Act and the STOCK Act, republished free for public transparency and news reporting. Disclosures may lag the trade by 45 days or more and show amounts only as ranges. This data may not be used for credit rating, loan underwriting, solicitation of money (political, charitable or other), direct-mail or commercial targeting (5 U.S.C. 13107).